<p>Advancements of Annexin A1 in inflammation and tumorigenesis</p>
نویسندگان
چکیده
منابع مشابه
Annexin A1 regulates intestinal mucosal injury, inflammation, and repair.
During mucosal inflammation, a complex array of proinflammatory and protective mechanisms regulates inflammation and severity of injury. Secretion of anti-inflammatory mediators is a mechanism that is critical in controlling inflammatory responses and promoting epithelial restitution and barrier recovery. AnxA1 is a potent anti-inflammatory protein that has been implicated to play a critical im...
متن کاملInflammation in Sickle Cell Disease: Differential and Down-Expressed Plasma Levels of Annexin A1 Protein
Sickle cell disease (SCD) is an inherited hemolytic anemia whose pathophysiology is driven by polymerization of the hemoglobin S (Hb S), leading to hemolysis and vaso-occlusive events. Inflammation is a fundamental component in these processes and a continuous inflammatory stimulus can lead to tissue damages. Thus, pro-resolving pathways emerge in order to restore the homeostasis. For example t...
متن کاملCorrection: Inflammation in Sickle Cell Disease: Differential and Down-Expressed Plasma Levels of Annexin A1 Protein
[This corrects the article DOI: 10.1371/journal.pone.0165833.].
متن کاملAnnexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance
Neutrophils (also named polymorphonuclear leukocytes or PMN) are essential components of the immune system, rapidly recruited to sites of inflammation, providing the first line of defense against invading pathogens. Since neutrophils can also cause tissue damage, their fine-tuned regulation at the inflammatory site is required for proper resolution of inflammation. Annexin A1 (AnxA1), also know...
متن کاملIncreased Adiposity in Annexin A1-Deficient Mice
Production of Annexin A1 (ANXA1), a protein that mediates the anti-inflammatory action of glucocorticoids, is altered in obesity, but its role in modulation of adiposity has not yet been investigated. The objective of this study was to investigate modulation of ANXA1 in adipose tissue in murine models of obesity and to study the involvement of ANXA1 in diet-induced obesity in mice. Significant ...
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ژورنال
عنوان ژورنال: OncoTargets and Therapy
سال: 2019
ISSN: 1178-6930
DOI: 10.2147/ott.s202271